From crimping through delivery through calcified lesions, expansion and drug elution, drug-eluting stents endure substantial mechanical and chemical stress. Inherently brittle, traditional polymer coatings of drug eluting stents have been shown to develop surface imperfections and deformations, which under stress can crack and even peel away from the stent.
Such cracking and peeling can lead to uneven drug release that may result in under- and over-dosing of the vessel wall. Moreover, they were associated with inflammation and thrombogenicity
Cracking and Peeling of Durable and Bioabsorbable Polymer in Various Drug-Eluting Stents
eDES uniquely complements Medinol’s renowned WiZeCell stent design. With the unique combination of flexible narrow struts and wide supportive struts, the WiZeCell scaffolding minimizes variations in inter-strut gap size, even in vessel bends.
Leveraging the highly-uniform WiZeCell scaffolding, which better conforms to vessel anatomy and moves naturally with the vessel, eDES technology enables a more long-term surface integrity and enables predictable, uniform release of a limus drug to the vessel wall.
Images taken with scanning electron microscope
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